In 1850 Aetna began selling life insurance and today has grown to provide Health Insurance for 17.5 million subscribers. Aetna also provides dental insurance for over 14 million Americans. Aetna offers group health insurance in most of the United States and offers individual and family insurance in larger markets. Florida is one of the states where Aetna is available.

Administered by Golden Rule, UnitedHealtcare offers individual and family insurance throughout Florida. The company is based in Indianapolis and has offered family health insurance for over 60 years. UnitedHealthcare individual line of business includes Golden Rule, PacifiCare, American Medical Security (AMS), MAMSI, Oxford Health Plans, and UnitedHealthOne. The family of companies provide more than 70 million Americans with health insurance products. The US network consists of 560,000 physicians and healthcare professionals.

Founded in 1961 in Louisville, Kentucky, Humana now markets its health insurance in all 50 states. Over 11.3 million Americans are insured by Humana and have access to over 450,000 physicians. Humana ranked first in Florida for their Medicare prescription drug plan (2006 survey conducted by JD Power). For individual and family policies Humana markets as HumanaOne.

After 125 years Cigna is still growing strong in the U.S. Cigna is best known for individual and group health insurance, disability, life and accident coverage with solid benefits for individuals and families. These products are offered all across Florida and have very competitive rates, especially for individual and family insurance. Cigna's philosophy is that healthier individuals create healthier families, and healthier families create healthier communities. Everyday Cigna works to improve health, well-being, and a sense of security for healthcare in Florida.